a tool for identifying drug-targetable redox-active disulphides

Tubulin alpha-1D chain

Intramolecular

Cysteine 316 and cysteine 376

A redox-regulated disulphide may form within Tubulin alpha-1D chain between cysteines 316 and 376. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

34

PDB code

Structure name

human doublecortin n-dc repeat plus linker, and tubulin (2xrp) docked into an 8a cryo-em map of doublecortin-stabilised microtubules reconstructed in absence of kinesin

Structure deposition date

2012-05-09

Thiol separation (Å)

8

Half-sphere exposure sum ?

94

Minimum pK_a ?

11

% buried

100

Peptide accession

Residue number A

316

Residue number B

376

Peptide name

Tubulin alpha-1D chain

Ligandability

Cysteine 316 of Tubulin alpha-1D chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of Tubulin alpha-1D chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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